Effects of Maternal Lead Acetate Exposure during Lactation on Postnatal Development of Testis in Offspring Wistar Rats
نویسندگان
چکیده مقاله:
Objective(s) During recent years, there has been an increasing interest in contribution of environmental pollutants as heavy metals to human male infertility. Present study was aimed to investigate the effects of maternal lead acetate exposure during lactation on postnatal development of testis in offspring rats. Materials and Methods A total of 60 female rats randomly divided into four equal groups; control and three treatment groups received 20, 100 and 300 mg/kg/day lead acetate via drinking water from day 2 to day 21 of lactation. At 7, 14, 21, 28, 60, 90 and 120 days after birth, the testis weight and volume of offspring were measured and their epididymal semen analyzed. Following tissue processing, 5 μm sections were stained with haematoxylineosin and evaluated with quantitative techniques. Testicular parameters in different groups were compared by one-way ANOVA. Results Testis weight and volume of offspring decreased significantly in a dose-related manner in moderate (P< 0.05) and high (P< 0.01) doses groups. Dose-dependent significant reductions were seen in seminiferous tubules diameter and germinal epithelium height during neonatal, prepubertal and postpubertal periods in moderate (P< 0.05) and high (P< 0.01) doses groups until 90 and 120 days after birth, respectively. Significant decreases were observed in mean sperm density of offspring at puberty in moderate and high doses groups until 90 and 120 days after birth, respectively. Testosterone levels decreased significantly in a dose-related manner at puberty in moderate and high doses groups. Conclusion Present study showed maternal lead acetate exposure during lactation caused dose-related and long-term alterations of testicular parameters in offspring rats.
منابع مشابه
effects of maternal lead acetate exposure during lactation on postnatal development of testis in offspring wistar rats
objective(s) during recent years, there has been an increasing interest in contribution of environmental pollutants as heavy metals to human male infertility. present study was aimed to investigate the effects of maternal lead acetate exposure during lactation on postnatal development of testis in offspring rats. materials and methods a total of 60 female rats randomly divided into four equal g...
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The course of human development from conception to adulthood is extremely complex. The developing organism is particularly vulnerable to toxic insult because of rapid cell division and differentiation and severely affected during gestation and lactation. The aim of the present study was to evaluate lead toxicity on the female reproductive system during neonatal period. A total of 30 female mice...
متن کاملLong-term Developmental Effects of Lactational Exposure to Lead Acetate on Ovary in Offspring Wistar Rats
متن کامل
long-term developmental effects of lactational exposure to lead acetate on ovary in offspring wistar rats
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متن کاملLong-term Developmental Effects of Lactational Exposure to Lead Acetate on Ovary in Offspring Wistar Rats
BACKGROUND During the last decades, environmental contamination by lead generated from human activities has become an evident concern. The present study assessed the long-term effects of neonatal exposure to different doses of lead acetate on the ovaries of offspring rats. MATERIALS AND METHODS Pregnant female Wistar rats were randomly divided into a control and three experimental groups. The...
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عنوان ژورنال
دوره 14 شماره 2
صفحات 122- 131
تاریخ انتشار 2011-03-01
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